منابع مشابه
The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β-lactamase in Enterobacter cloacae
Induction of ampC β-lactamase expression can often compromise antibiotic treatment and is triggered by several β-lactams (such as cefoxitin and imipenem) and by the β-lactamase inhibitor clavulanic acid. The novel β-lactamase inhibitor avibactam (NXL104) is a potent inhibitor of both class A and class C enzymes. The potential of avibactam for induction of ampC expression in Enterobacter cloacae...
متن کاملEtymologia: β-Lactamase
Author affiliations: Justus Liebig University, Giessen, Germany (L. Falgenhauer, S.-E. Waezsada, K. Gwozdzinski, H. Ghosh, S. Doijad, C. Imirzalioglu, A. Goesmann, T. Chakraborty); German Center for Infection Research, Giessen, Germany (L. Falgenhauer, S.-E. Waezsada, K. Gwozdzinski, H. Ghosh, S. Doijad, C. Imirzalioglu, T. Chakraborty); Leibniz Institute DSMZ—German Collection of Microorganism...
متن کاملUse of β-Lactam/β-Lactamase Inhibitors for Extended-Spectrum-β-Lactamase Infections: Defining the Right Patient Population.
In a multicenter, multinational observational study that included neutropenic patients with bloodstream infections by extended-spectrum-β-lactamase-producing species, Gudiol et al. (Antimicrob. Agents Chemother. 61:e00164-17, 2017, https://doi.org/10.1128/AAC.00164-17) demonstrated that β-lactam/β-lactamase inhibitors are effective treatment options. A review of this work, however, reminds us t...
متن کاملAmpC β lactamases in Urinary Klebsiella pneumoniae Isolates: First Report of ACC Type AmpC β-lactamase Resistance in Iran
Background & Objective: The production of plasmid-mediated AmpC beta-lactamases (PMABLs) among urinary Klebsiella pneumoniae isolates causes a severe problem to the successful treatment of urinary tract infections (UTIs). This study was designed to evaluate antimicrobial resistance, the presence of AmpC beta-lactamase genes, and the genetic relatedness among K. pneumoniae strains separated from...
متن کاملNovel β-Lactamase blaARL in Staphylococcus arlettae
Whole-genome sequencing of penicillin-resistant Staphylococcus arlettae strain SAN1670 from bovine mastitis milk revealed a novel β-lactamase operon consisting of the β-lactamase-encoding gene blaARL, the antirepressor-encoding gene blaR1ARL, and the repressor-encoding gene blaIARL. The functionality of blaARL was demonstrated by gene expression in Staphylococcus aureus. The blaARL operon was c...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1989
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/24.6.831